> ## Documentation Index > Fetch the complete documentation index at: https://docs.kallima.bio/llms.txt > Use this file to discover all available pages before exploring further. # Submit a stability analysis job > Submit a stability analysis against a variant. Returns ``202 Accepted`` with ``status=pending``; poll ``GET /v1/stability-analyses/{id}`` until terminal. **Plan gate.** Stability analysis requires the Structure plan or above; lower plans receive ``402 plan_upgrade_required``. **Credits.** Stability analysis costs 3 credits per submission. Insufficient credits surface as ``402 insufficient_credits``. Cost: **write** — burns rate + quota, and debits credits. ## OpenAPI ````yaml /api-reference/openapi.json post /v1/stability-analyses openapi: 3.1.0 info: title: Kallima API description: >- Antibody design API — humanization, structure, stability, immunogenicity, complex prediction, and codon optimization. version: 0.1.0 servers: [] security: [] tags: - name: identity description: >- Caller identity and credit balance — use ``GET /v1/me`` to inspect the resolved org, plan, and compute budget before submitting jobs. - name: projects description: >- Projects — top-level containers for source antibodies and therapeutic candidates. - name: source-antibodies description: Source (parental) antibody sequences registered under a project. - name: variants description: >- Variants descended from a therapeutic candidate — the unit of work for pipelines. - name: jobs description: >- Long-running pipeline jobs: humanization, structure, stability, immunogenicity. Submit and poll. Deprecated in favor of resource-per-job-type endpoints (``humanizations`` and the other Phase 3 resources); scheduled for removal in ``/v2``. - name: humanizations description: >- Humanization pipeline runs — typed submit body and typed per-strategy results. First of the Phase 3 resource-per-job-type endpoints; the generic ``/v1/jobs`` shape is deprecated in favor of this. - name: structure-predictions description: >- ImmuneBuilder structure predictions — typed submit body and typed PDB / pLDDT / CDR results. Phase 3 resource-per-job-type endpoint. - name: stability-analyses description: >- Stability analyses — typed submit body and typed thermostability / aggregation / developability scorecard. Phase 3 resource-per-job-type endpoint. - name: immunogenicity-analyses description: >- Immunogenicity analyses — typed submit body and typed MHC-I / MHC-II / B-cell epitope + risk-score results. Phase 3 resource-per-job-type endpoint. - name: uploads description: >- Presigned Supabase Storage slots for caller-supplied files (e.g. antigen PDBs for complex prediction). The API never proxies bytes — clients PUT directly to the returned URL. - name: antigens description: >- Target protein sequences scoped to a project — the docking partner in a complex prediction. Register once, reference by ``antigen_id`` at submit time. - name: complex-predictions description: >- Boltz-2 antibody-antigen complex predictions — typed submit body and typed docked-PDB / iptm / interface-residues results. Phase 3 resource-per-job-type endpoint. Complex runs are long-running (~20–40 min on GPU); always poll, never hold the connection. - name: therapeutic-candidates description: >- Therapeutic candidates — the top-of-lineage object under a project. Creating one auto-creates a baseline variant (``v1``) and its chain rows atomically; pipelines submit against the variant. Junction endpoints manage many-to-many links to source antibodies and antigens. - name: adc-designs description: >- ADC (antibody-drug conjugate) designs — catalog records attaching a linker + payload + conjugation method to a therapeutic candidate. Run the rule-based developability analysis via ``POST /v1/adc-designs/{id}/analysis``; pass ``structure_job_id`` to include SASA-based conjugation-site accessibility. - name: codon-exports description: >- Codon optimization exports — submit a batch of jobs (one per variant), poll until ``variable_cds`` is populated, then download the assembled CDS as FASTA, CSV, or GenBank+ZIP. Requires the Structure plan or above. - name: webhooks description: >- Webhook endpoint registration — register HTTPS URLs to receive signed event deliveries when jobs complete or fail. Signing uses HMAC-SHA256; see ``POST /v1/webhooks`` for verification details. - name: webhook-deliveries description: >- Webhook delivery log — inspect past delivery attempts and manually retry failed ones via ``POST /v1/webhook_deliveries/{id}/retry``. paths: /v1/stability-analyses: post: tags: - stability-analyses summary: Submit a stability analysis job description: |- Submit a stability analysis against a variant. Returns ``202 Accepted`` with ``status=pending``; poll ``GET /v1/stability-analyses/{id}`` until terminal. **Plan gate.** Stability analysis requires the Structure plan or above; lower plans receive ``402 plan_upgrade_required``. **Credits.** Stability analysis costs 3 credits per submission. Insufficient credits surface as ``402 insufficient_credits``. Cost: **write** — burns rate + quota, and debits credits. operationId: submit_stability_analysis_v1_stability_analyses_post requestBody: required: true content: application/json: schema: $ref: '#/components/schemas/StabilityAnalysisSubmit' responses: '202': description: Successful Response content: application/json: schema: $ref: '#/components/schemas/StabilityAnalysis' '400': description: Malformed request body or parameter. content: application/problem+json: schema: $ref: '#/components/schemas/ProblemDetails' '401': description: Missing or invalid API token. content: application/problem+json: schema: $ref: '#/components/schemas/ProblemDetails' '402': description: >- Payment required — insufficient credits or the caller's plan is below the required tier. content: application/problem+json: schema: $ref: '#/components/schemas/ProblemDetails' '404': description: Resource does not exist in the caller's organization. content: application/problem+json: schema: $ref: '#/components/schemas/ProblemDetails' '422': description: Request failed validation. content: application/problem+json: schema: $ref: '#/components/schemas/ProblemDetails' '429': description: >- Rate limit or monthly write quota exceeded. `Retry-After` holds the number of seconds until the next admitted request. content: application/problem+json: schema: $ref: '#/components/schemas/ProblemDetails' headers: Retry-After: description: Seconds until the caller may retry. Present on 429 responses. schema: type: integer minimum: 1 X-RateLimit-Limit: description: Per-minute rate ceiling for this API token's plan. schema: type: integer X-RateLimit-Remaining: description: Requests remaining in the current rate window. schema: type: integer X-RateLimit-Reset: description: HTTP-date when the rate window resets. schema: type: string format: http-date X-Quota-Limit: description: Monthly write ceiling for this API token's plan. schema: type: integer X-Quota-Remaining: description: Writes remaining in the current monthly window. schema: type: integer X-Quota-Reset: description: >- HTTP-date when the monthly write quota resets (always the 1st of next month UTC). schema: type: string format: http-date security: - HTTPBearer: [] components: schemas: StabilityAnalysisSubmit: properties: variant_id: type: string title: Variant Id description: >- UUID of the variant to analyze. Must belong to the caller's org. Fc-fusion constructs are not supported. examples: - 11112222-3333-4444-5555-666677778888 type: object required: - variant_id title: StabilityAnalysisSubmit description: Body for ``POST /v1/stability-analyses``. example: variant_id: 11112222-3333-4444-5555-666677778888 StabilityAnalysis: properties: id: type: string title: Id description: Opaque stability-analysis identifier (UUID). examples: - bbbb2222-cccc-3333-dddd-444455556666 object: type: string const: stability_analysis title: Object description: Polymorphic discriminator. Always ``stability_analysis``. default: stability_analysis status: type: string enum: - pending - running - completed - failed - canceled title: Status description: >- Lifecycle state. ``pending`` → ``running`` → ``completed`` | ``failed``. ``canceled`` is terminal and only reachable via ``POST /v1/stability-analyses/{id}/cancel`` on a still-pending job. examples: - pending created_at: type: string title: Created At description: ISO-8601 timestamp (UTC) when the job was submitted. examples: - '2026-04-22T14:15:00+00:00' started_at: anyOf: - type: string - type: 'null' title: Started At description: ISO-8601 timestamp when execution started. ``null`` while pending. completed_at: anyOf: - type: string - type: 'null' title: Completed At description: ISO-8601 timestamp when the job completed successfully. failed_at: anyOf: - type: string - type: 'null' title: Failed At description: >- ISO-8601 timestamp when the job failed. ``null`` unless ``status=failed``. canceled_at: anyOf: - type: string - type: 'null' title: Canceled At description: >- ISO-8601 timestamp when the job was canceled. ``null`` unless ``status=canceled``. error: anyOf: - $ref: '#/components/schemas/StabilityAnalysisError' - type: 'null' description: Populated only when ``status=failed``. Same shape as problem+json. credit_cost: type: integer title: Credit Cost description: Credits debited at submission for this job type. examples: - 3 inputs: $ref: '#/components/schemas/StabilityAnalysisInputs' description: Echo of the caller's submit body. results: anyOf: - $ref: '#/components/schemas/StabilityAnalysisResult' - type: 'null' description: Stability scorecard. ``null`` until ``status=completed``. type: object required: - id - status - created_at - credit_cost - inputs title: StabilityAnalysis description: Stability analysis job envelope — pipeline status + typed result. example: completed_at: '2026-04-22T14:16:42+00:00' created_at: '2026-04-22T14:15:00+00:00' credit_cost: 3 id: bbbb2222-cccc-3333-dddd-444455556666 inputs: variant_id: 11112222-3333-4444-5555-666677778888 object: stability_analysis results: aggregation_score: 0.18 developability_score: 84 melting_temp_predicted: 72.4 model_versions: thermomab: 0.3.1 solubility_score: 0.71 stabilizing_mutations: [] thermostability_score: 0.82 started_at: '2026-04-22T14:15:02+00:00' status: completed ProblemDetails: additionalProperties: true description: RFC 9457 problem+json body returned by every non-2xx response. example: code: insufficient_credits credit_balance: 0 credit_cost: 1 detail: Humanization costs 1 credit; balance is 0. instance: /v1/jobs request_id: req_01JBX6Y6ZK6N8Q7YJ0F5VX2C3D status: 402 title: Insufficient credits type: https://docs.kallima.bio/errors/insufficient_credits properties: type: description: >- Stable URI identifying the error class. Dereferenceable at docs.kallima.bio/errors/{code}. examples: - https://docs.kallima.bio/errors/insufficient_credits title: Type type: string title: description: Short human-readable summary of the error class. examples: - Insufficient credits title: Title type: string status: description: HTTP status code. Matches the response status line. examples: - 402 title: Status type: integer detail: description: Human-readable explanation with values substituted. examples: - Humanization costs 1 credit; balance is 0. title: Detail type: string instance: description: The specific request URI that failed. examples: - /v1/jobs title: Instance type: string code: description: >- Machine-readable short code. SDKs switch on this, not on `title`. See app.errors.ErrorCode for the full taxonomy. examples: - insufficient_credits title: Code type: string request_id: anyOf: - type: string - type: 'null' default: null description: ULID stamped on every request. Include when contacting support. examples: - req_01JBX6Y6ZK6N8Q7YJ0F5VX2C3D title: Request Id required: - type - title - status - detail - instance - code title: ProblemDetails type: object StabilityAnalysisError: properties: type: type: string title: Type description: Stable URI identifying the error class. examples: - https://docs.kallima.bio/errors/job_failed title: type: string title: Title description: Short human summary. examples: - Job failed status: type: integer title: Status description: HTTP-like status code. examples: - 500 detail: type: string title: Detail description: Human-readable failure reason, from the executor. examples: - Stability analysis is not supported for Fc-fusion constructs. code: type: string title: Code description: Machine-readable code. SDKs switch on this. examples: - job_failed type: object required: - type - title - status - detail - code title: StabilityAnalysisError description: Problem-details-shaped error surfaced on a failed stability job. StabilityAnalysisInputs: properties: variant_id: type: string title: Variant Id description: Variant the stability analysis ran against. examples: - 11112222-3333-4444-5555-666677778888 type: object required: - variant_id title: StabilityAnalysisInputs description: What the caller submitted when creating this stability analysis. StabilityAnalysisResult: properties: ddg_matrix: anyOf: - additionalProperties: true type: object - type: 'null' title: Ddg Matrix description: Per-position ΔΔG-from-saturation mutagenesis matrix. solubility_score: anyOf: - type: number - type: 'null' title: Solubility Score description: Predicted solubility (0–1). aggregation_score: anyOf: - type: number - type: 'null' title: Aggregation Score description: Aggregation-propensity score. thermostability_score: anyOf: - type: number - type: 'null' title: Thermostability Score description: Composite thermostability score. melting_temp_predicted: anyOf: - type: number - type: 'null' title: Melting Temp Predicted description: Predicted melting temperature (°C). developability_score: anyOf: - type: number - type: 'null' title: Developability Score description: Composite developability score (0–100). stabilizing_mutations: anyOf: - items: additionalProperties: true type: object type: array - type: 'null' title: Stabilizing Mutations description: Top suggested stabilizing point mutations with ΔΔG deltas. model_versions: anyOf: - additionalProperties: type: string type: object - type: 'null' title: Model Versions description: Versions of the underlying predictors (e.g., ``thermomab``). structure_result_id: anyOf: - type: string - type: 'null' title: Structure Result Id description: >- ID of the structure-prediction result row consumed by this analysis, if stability ran against a prior predicted PDB. ``null`` when stability fell back to sequence-only scoring. type: object title: StabilityAnalysisResult description: Stability scorecard — thermostability, aggregation, developability. securitySchemes: HTTPBearer: type: http scheme: bearer ````